b-Amyloid Load Is Not Influenced by the Severity of Cardiovascular Disease in Aged and Demented Patients

Background and Purpose—This study was conducted to analyze the association between reported risk factors for Alzheimer’s disease, apolipoprotein E e4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer’s disease. Methods—Our data are based on clinical and postmortem evaluations of a cohort of nondemented (n5118) and demented (n5107) individuals. A cardiovascular index was calculated at autopsy to estimate the extent of cardiovascular disease. Neuropathological lesions such as senile/neuritic plaques, neurofibrillary tangles, b-amyloid load, cerebral amyloid angiopathy, and the load of paired helical filaments were determined. Results—The aforementioned neuropathological lesions did not show any positive significant correlation with cardiovascular index. In contrast, the extent of Alzheimer’s lesions was significantly higher in those nondemented and demented patients carrying the apolipoprotein E e4 allele than in those without this allele. Conclusions—Our results demonstrate that the apolipoprotein E e4 allele, but not cardiovascular disease, indeed influences the extent of Alzheimer’s lesions seen in the brain tissue of demented patients as well as asymptomatic controls. (Stroke. 1999;30:613-618.)